Sleep disturbance disrupts various activities in the central nervous system, including waste molecule elimination. One of the most important prerequisites for healthy aging is the preservation of robust circadian rhythmicity (particularly of the sleep/wake cycle). As a result, any effective approach to healthy aging must consider both the correction of circadian disturbance and the control of low-grade inflammation. Daniel P Cardinali, 1 Gregory M Brown, 2 Seithikurippu R Pandi-Perumal 3ġFaculty of Medical Sciences, Pontificia Universidad Católica Argentina, Buenos Aires, Argentina 2Molecular Brain Science Research Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada 3Department of Psychiatry, University of Toronto, Toronto, Ontario, CanadaĬorrespondence: Seithikurippu R Pandi-Perumal, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India, Email Ībstract: Aging is accompanied by circadian changes, including disruptive alterations in the sleep/wake cycle, as well as the beginning of low-degree inflammation (“inflammaging”), a scenario that leads to several chronic illnesses, including cancer, and metabolic, cardiovascular, and neurological dysfunctions.
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